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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells

Figure 2

Combination of PAFR and EGFR targeting decreases cell growth and invasion in CAOV-3 and SKOV-3 cell lines. Cells were treated with WEB2086 (0.1 mM), AG1478 (10 μM), and their combination. (A and B) The percentage of cell survival was measured by the CCK-8 assay 72 hours later. Independent experiments were repeated three times. Columns, means of 3 identical wells of a single representative experiment; bars, upper 95% confidence interval; **, p < 0.005 for comparisons between cells treated with the combined treatment and cells treated with the single agent. (C and D) Cells were plated in Matrigel invasion chambers and invading cells were counted using light microscopy. Columns, means of 3 identical wells of a single representative experiment; bars, upper 95% confidence interval; ***, p < 0.001 for comparisons between cells treated with the combined treatment and cells treated with the single agent.

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