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Figure 6 | Journal of Hematology & Oncology

Figure 6

From: Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells

Figure 6

Effects on downstream pathways by combined PAFR and EGFR targeting. (A) CAOV-3 cell lysates were harvested 24 h after AG1478 (10 μM), WEB2086 (0.1 mM), or combination treatment. Cell lysates were subjected to immunoblotting with phospho/total -EGFR, phospho-β- arrestin2, PAFR, phospho/total-P70S6K, phospho/total-AKT, phospho/total-ERK. β-Actin was included as a loading control. (B) SKOV-3 cell lysates were harvested 24 h after AG1478 (10 μM), WEB2086 (0.1 mM), or combination treatment. Cell lysates were subjected to immunoblotting with the antibodies used in A.

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