Figure 7From: Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cellsEffects of the combined PAFR and EGFR targeting on ovarian cancer xenografts. Athymic nude mice were injected subcutaneously into the flank with CAOV-3 cells. (A) Representative photographs of tumors extracted from mice treated with or without WEB2086 (5 mg/kg, i.p., every three days for 2 weeks) and AG1478 (10 mg/kg, i.p., every three days for 2 weeks). (B) Ovarian cancer volume was determined in mice administered WEB2086 and/or AG1478. The data represent the average (±SD). Student’s t-test was used to compare tumor sizes among the different treatment groups at day 21 following the start of treatment. ***, p < 0.001 indicates a statistically significant difference compared to the treatment with the single agent.Back to article page