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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels

Figure 4

WT1 / AWT1 methylation profiling in primary hematological cancers. (A) Circular heat map of pyrosequencing results for all samples analyzed indicating disease classification and underlying mutation or translocation. The inner circle represents the methylation values of the WT1 CpG promoter and the outer circle the AWT1 promoter. (B) Box plot representing the methylation levels at the AWT1 promoter in normal leukocytes (NL) and in hematological cancers. (C) Box plots for the WT1 methyaltion profiles in the same sample cohort. The differences between groups were evaluated using the Mann–Whitney T-test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

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