Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding

Table 5 Candidate SNPs in miRNA target sequences

Gene symbol	SNP ID	Predicted effect on miRNA binding
Gene symbol	SNP ID	miRanda	PITA	Partocles	PolymiRTS
ABL1	rs7457 C > T	*miR-23a/b ↑*	*miR-23a/b ↑*		*miR-23a/b ↑*
ABL1	rs7457 C > T	miR-96 ↑			miR-323 ↑
ARHGAP26	rs187729 T > C	miR-579 ↑		*miR-18a/b ↑*	*miR-18 ↑*
ATM	rs227091 T > C	*miR-510 ↑*	miR-214 ↑	*miR-510 ↑*	*miR-510 ↑*
		miR-665↑	*miR-510 ↑*		miR-512-5p ↑
			miR-665↑
			miR-744 ↓
			miR-939 ↓
ETV6	rs1573613 T > C	*miR-34a/c ↓*	*miR-34a/c ↓*	*miR-34b ↓*	*miR-34a/b/c ↓*
		*miR-449a/b ↓*	miR-885-3p ↓		*miR-449b ↓*
		miR-1207-5p ↓	miR-1207-5p ↓
			let-7b ↓
IRF4	rs1877176 G > A	miR-101 ↑		*miR-429 ↑*	miR-141 ↓
		miR-107 ↓			miR-200b/c ↓
		miR-141 ↓			*miR-429 ↑*
		miR-338-5p ↑
		miR-369-3p ↑
		*miR-429 ↑*
IRF8	rs10514611 C > T	*miR-330-3p ↑*		*miR-330-3p ↑*	*miR-330-3p ↑*
IRF8	rs10514611 C > T	miR-562 ↑
NBN	rs2735383 G > C	miR-499-5p ↑
		miR-509-5p ↑
		miR-629 ↓
PML	rs9479 G > A	miR-24 ↓	miR-383 ↑	*miR-589-3p ↓*	*miR-589-3p ↓*
		*miR-510 ↓*	*miR-510 ↓*
		miR-602 ↓	miR-513a-5p ↓ miR-1182↑
TLX1	rs1051723 C > T	*miR-539 ↑*		*miR-539 ↑*	*miR-539 ↑*
TLX1	rs1051723 C > T	miR-1300 ↓
TLX1	rs2742038 C > T	miR-591 ↑	*miR-492 ↑*		*miR-492 ↑*

Predicted impact of the variant allele on miRNA binding by different algorithms: ↑ binding enhanced, ↓ binding weakened, miRNAs expressed in bone marrow, white blood cells or leukemias and lymphomas are in bold, miRNAs predicted by more than one algorithm are in italics.

ISSN: 1756-8722