Table 6 Distribution of genotypes of 10 selected miRSNPs in cases and controls and their association with leukemia risk
SNP | Genotype | Controls (n = 471) | ALL (n = 101) | AML (n = 87) | CML (n = 140) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | AdjustedaOR (95% CI) | p value | n (%) | AdjustedbOR (95% CI) | p value | n (%) | AdjustedbOR (95% CI) | p value | ||
Genetic model | (Corrected) | Genetic model | (Corrected) | Genetic model | (Corrected) | ||||||
ABL1 _rs7457 C > T | CC | 402 (85.3%) | 86 (85.1%) | 1.3174 (0.2688-6.4561) | 0.7339 | 78 (89.7%) | 0.5735 (0.2744-1.1984) | 0.1392 | 111 (79.3%) | 1.5191 (0.9371-2.4627) | 0.0898 |
CT | 62 (13.2%) | 13 (12.9%) | recessive | (0.7858) | 9 (10.3%) | additive | (0.5367) | 27 (19.3%) | dominant | (0.2993) | |
TT | 7 (1.5%) | 2 (2%) | 0 (0%) | 2 (1.4%) | |||||||
ARHGAP26 _rs187729 T > C | TT | 110 (23.4%) | 24 (23.75%) | 1.0728 (0.6463-1.7807) | 0.7858 | 26 (30.2%) | 0.6946 (0.4173- | 0.161 | 30 (21.4%) | 1.6297 (1.0755-2.4695) | 0.0213 |
CT | 255 (54.1%) | 53 (52.5%) | recessive | (0.7858) | 40 (46.5%) | 1.1562) | (0.5367) | 65 (46.4%) | recessive | (0.123) | |
CC | 106 (22.5%) | 24 (23.75%) | 20 (23.3%) | dominant | 45 (32.2%) | ||||||
ATM _rs227091 T > C | TT | 151 (32.2%) | 21 (22.6%) | 1.6473 (0.9892-2.7430) | 0.0551 | 27 (31%) | 0.7452 (0.3866-1.4366) | 0.3799 | 48 (34.3%) | 0.9103 (0.6104-1.3573) | 0.6446 |
CT | 236 (50.3%) | 52 (55.9%) | additive | (0.1377) | 48 (55.2%) | recessive | (0.5922) | 67 (47.9%) | dominant | (0.8057) | |
CC | 82 (17.5%) | 20 (12.5%) | 12 (13.8%) | 25 (17.8%) | |||||||
ETV6 _rs1573613 T > C | TT | 158 (33.7%) | 35 (34.7%) | 1.8994 (1.1606-3.1085) | 0.0107 | 26 (30.2%) | 1.2629 (0.7114-2.2421) | 0.4254 | 44 (31.4%) | 0.7416 (0.4325-1.2715) | 0.2771 |
CT | 229 (48.8%) | 37 (36.6%) | recessive | (0.0356) | 42 (48.9%) | recessive | (0.5922) | 77 (55%) | recessive | (0.5542) | |
CC | 82 (17.5%) | 29 (28.7%) | 18 (20.9%) | 19 (13.6%) | |||||||
IRF4 _rs1877176 G > A | GG | 331 (70.3%) | 75 (74.3%) | 0.7758 (0.4792-1.2560) | 0.3017 | 60 (69%) | 1.4661 (0.4608-4.6649) | 0.5170 | 101 (72.1%) | 1.2897 (0.4478-3.7139) | 0.6373 |
AG | 127 (27%) | 25 (24.7%) | additive | (0.3771) | 23 (26.4%) | recessive | (0.5922) | 34 (24.3%) | recessive | (0.8057) | |
AA | 13 (2.7%) | 1 (1%) | 4 (4.6%) | 5 (3.6%) | |||||||
IRF8 _rs10514611 C > T | CC | 280 (59.6%) | 56 (56%) | 2.1876 (0.9232-5.1836) | 0.0753 | 50 (57.5%) | 1.1150 (0.7093-1.7526) | 0.6373 | 84 (60%) | 2.4008 (1.1189-5.1514) | 0.0246 |
CT | 172 (36.6%) | 36 (36%) | recessive | (0.1656) | 33 (37.9%) | additive | (0.6373) | 44 (31.4%) | recessive | (0.123) | |
TT | 18 (3.8%) | 8 (8%) | 4 (4.6%) | 12 (8.6%) | |||||||
NBN _rs2735383 G > C | GG | 184 (39.2%) | 32 (31.7%) | 1.4140 (0.9089-2.2000) | 0.1245 | 40 (46.5%) | 0.7450 (0.4678-1.1863) | 0.2148 | 56 (40%) | 1.0854 (0.6492-1.8147) | 0.7548 |
CG | 214 (45.5%) | 50 (49.5%) | additive | (0.1778) | 32 (37.2%) | dominant | (0.537) | 61 (43.6%) | recessive | (0.8387) | |
CC | 72 (15.3%) | 19 (18.8%) | 14 (16.3%) | 23 (16.4%) | |||||||
PML _rs9479 G > A | GG | 113 (24%) | 37 (36.6%) | 0.5527 (0.3569-0.8560) | 0.0079 | 30 (34.5%) | 0.6055 (0.3778-0.9706) | 0.0372 | 37 (26.4%) | 0.7626 (0.4759-1.2221) | 0.26 |
AG | 246 (52.2%) | 43 (42.6%) | additive | (0.0356) | 39 (44.8%) | additive | (0.372) | 76 (54.3%) | recessive | (0.5542) | |
AA | 112 (23.8%) | 21 (20.8%) | 18 (20.7%) | 27 (19.3%) | |||||||
TLX1 _rs1051723 C > T | CC | 224 (47.5%) | 56 (56%) | 0.7097 (0.4672-1.0782) | 0.1081 | 38 (43.7%) | 1.1586 (0.7294-1.8405) | 0.533 | 66 (47.1%) | 1.0198 (0.7076-1.4696) | 0.9164 |
CT | 208 (44.2%) | 37 (37%) | additive | (0.1778) | 43 (49.4%) | dominant | (0.5922) | 62 (44.3%) | additive | (0.9164) | |
TT | 39 (8.3%) | 7 (7%) | 6 (6.9%) | 12 (8.6%) | |||||||
TLX1 _rs2742038 C > T | CC | 325 (69%) | 61 (60.4%) | 3.9718 (1.4314-11.0211) | 0.0081 | 58 (66.7%) | 1.9108 (0.5019-7.2750) | 0.3424 | 97 (69.3%) | 0.3696 (0.0464-2.9453) | 0.3472 |
CT | 137 (29.1%) | 33 (32.7%) | recessive | (0.0356) | 26 (29.9%) | recessive | (0.5922) | 42 (30%) | recessive | (0.5787) | |
TT | 9 (1.9%) | 7 (6.9%) | 3 (3.4%) | 1 (0.7%) | |||||||