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Table 7 Cumulative effect of risk genotypes

From: Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding

Leukemia

Number of risk genotypes carried

Controls (n = 468) n(%)

Patients n (%)

Adjusted OR (95% CI)

p value

ALLa

0

91 (19.4%)

5 (5.4%)

ref.c

 

n = 93

1

234 (50%)

47 (50.5%)

3.67 (1.41-9.53)

0.0327

 

2

126 (26.9%)

28 (30.1%)

4 (1.48-10.75)

0.0004

 

3 or 4

17 (3.6%)

13 (14%)

13.91 (4.38-44.11)

<0.0001

CMLb

0

348 (74.4%)

88 (62.9%)

ref.d

 

n = 140

1

116 (24.8%)

47 (33.6%)

1.6 (1.06-2.41)

0.0261

 

2

4 (0.8%)

5 (3.6%)

4.9 (1.27-18.85)

0.0209

  1. OR, odds ratio; CI, 95% confidence interval. Statistically significant results are in bold.
  2. aRisk genotypes defined as ETV6 _rs1573613 CC, PML _rs9479 GG, TLX1 _rs2742038 TT, ATM _rs227091 CC and CT, and IRF8 _rs10514611 TT.
  3. bRisk alleles defined as ARHGAP26 _rs187729 CC and IRF8 _rs10514611 TT.
  4. cOR adjusted for sex.
  5. dOR adjusted for sex and age.