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Figure 5 | Journal of Hematology & Oncology

Figure 5

From: The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease

Figure 5

Effects of Shb deletion on disease progression of BCR-ABL-transformed bone marrow cells transplanted to Shb knockout recipient mice. (a) Kaplan-Meier curve demonstrating survival of Shb knockout mice receiving either wild type or Shb knockout BCR-ABL-transformed bone marrow. (b) White blood cell counts in peripheral blood at the time of death. (c) Relative numbers of mature neutrophils and blasts in peripheral blood at the time of death. (d) Colony formation assay of c-Kit enriched bone marrow cells grown in cytokine-supplemented methylcellulose. (e) Cytokine mRNA levels in c-kit-enriched bone marrow cells.

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