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Figure 6 | Journal of Hematology & Oncology

Figure 6

From: XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)

Figure 6

In vitro experiments: Selinexor (KPT-330) amplified anoikis in prostatic cancer cells with high metastatic potential. (A) this panel shows the cell death percentage in PC3, PCb2 and DU145 cells treated or not with 20 or 50 nM KPT-330, corresponding to IC10 and IC20 values for this compound[18], and grown in non adhesion conditions (anoikis). (B) This panel shows the cell death percentage obtained in the same cells treated or not with KPT and grown in adhesion conditions (apoptosis). (C) This panel show the FACS analyses evaluated in DU145 treated with 20 and 50 nM KPT-330 grown in non adhesion conditions (anoikis). (D) Selinexor reduces migration and tumor invasion by reducing MMP-9, MMP-2 and uPA secretion.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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