BENC-511 induces MM cell apoptosis in the presence of IL-6 or IGF-1. (A) OPM2 cells were co-treated with IL-6, IGF-1 and BENC-511 with the increasing concentration for 24 hours. After incubation, cells were harvested and cell lysates were measured for the expression of PARP and GAPDH by Western blotting. (B) MM cell lines OPM2 was co-cultured overnight with human bone marrow stromal cell HS-5, followed by treatment with BENC-511 overnight. Cells were then collected for PARP, p-AKT (S473) and total AKT (T-AKT) analysis.