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Table 1 Toxicology of BENC-511 in nude mice: hematology analysis

From: Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization

Treatment WBC (109/L) RBC (1012/L) HGB (g/L) PLT (109/L)
Control 1.81 ± 0.65 7.54 ± 1.37 110.00 ± 18.80 511.92 ± 134.68
BENC-511 1.70 ± 0.50 8.18 ± 1.97 123.80 ± 29.78 530.50 ± 112.82
P 0.89 0.68 0.47 0.58
  1. Data represent mean ± SD of 6 nude in each group. Female nude mice (n = 6 mice per group) were treated with BENC-511 at 50 mg/kg body weight or vehicle for 20 days. Blood samples were collected in tubes containing EDTA as anticoagulant and subject to hematological analysis. WBC: White blood cell; RBC: Red blood cell; PLT: Platelets; HGB: haemoglobin.