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Table 1 Toxicology of BENC-511 in nude mice: hematology analysis

From: Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization

Treatment

WBC (109/L)

RBC (1012/L)

HGB (g/L)

PLT (109/L)

Control

1.81 ± 0.65

7.54 ± 1.37

110.00 ± 18.80

511.92 ± 134.68

BENC-511

1.70 ± 0.50

8.18 ± 1.97

123.80 ± 29.78

530.50 ± 112.82

P

0.89

0.68

0.47

0.58

  1. Data represent mean ± SD of 6 nude in each group. Female nude mice (n = 6 mice per group) were treated with BENC-511 at 50 mg/kg body weight or vehicle for 20 days. Blood samples were collected in tubes containing EDTA as anticoagulant and subject to hematological analysis. WBC: White blood cell; RBC: Red blood cell; PLT: Platelets; HGB: haemoglobin.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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