Figure 2

IMP3 signatures in fallopian tube. These tubal sections were derived from high-risk group (a), (b), PSC (c), (e), (f), and low-risk group (d). Panel (b) shows IMP3 signatures (arrow) in the low-mid area and the corresponding H&E staining shows morphologically unremarkable tubal epithelial cells (a). Panel (d) shows sporadic cytoplasmic staining of IMP3 in a non-continuous pattern, which is not qualified as IMP3 signatures. Panel (c) shows multiple foci of IMP3 signatures with some corresponding to IMP3-SCE (single arrow, 10–30 positive cells in a row) and some corresponding to IMP3-SCOUTs (double arrow, ≥30 positive cells), which are magnified into panel (e) and panel (f), respectively.