Table 1 Efficiency of different iPS induction methods in fibroblasts

Virus

M

OSKM/retrovirus

0.001 ~ 0.01

[[1]]

H

OSKM/retrovirus

0.02

[[2]]

H

OSNL/lentivirus

0.01 ~ 0.02

[[3]]

M, H

OSK/retrovirus

<0.001

[[25]]

M

OSK/retrovirus + VPA

2

[[26]]

H

OSK/retrovirus + VPA

1

[[19]]

OS/retrovirus + VPA

<0.001

M

OSKM/adenovirus

0.0001 ~ 0.001

[[27]]

H

OSKM/retrovirus/p53 siRNA and UTF1

2

[[28]]

M

OSKM/a single polycistronic retrovirus

0.0001

[[29]]

M

OSKM/retrovirus/p53 siRNA

20

[[30]]

OSK/retrovirus/p53 siRNA

10

H

OSKM/SeV

~1%

[[31]]

M

pMX-OSKM cDNA/retrovirus + Vc

8.75

[[32]]

H

OSKM/retrovirus + VPA + Vc

6.2

[[33]]

Plasmids

M

pCX-cMyc + pCX-OSK-2A

0.0001 ~ 0.0003

[[34]]

EV

H

IRES2 -mediated OSNLKM + SV40LT

0.0003-0.0006

[[35]]

Protein

M

OSKM + VPA/recombinant protein

0.006

[[36]]

OSK + VPA/recombinant protein

0.001

H

OSKM/cell extract

0.001

[[37]]

Modified-RNA

H

OSKML

2(KSOML), 1.4(KSOM)

[[38]]

Minicircle DNA

H

OSNL

~0.0005

[[39]]

Artificial chromosome vectors

H

OSKM

0.001%.

[[40]]

Small-molecule compounds

M

7 small-molecule compounds

0.2

[[41]]