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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients

Figure 1

BCL11b expression in the stages of normal T-cell development. In the murine model BCL11b expression begins during the transition of DN1 to DN2 and continues throughout further differentiation steps and in mature T-cells [[39]]. Knockout at DN2 stage leads to a NK like phenotype with differentiation arrest and a high proliferative potential [[13]]. The corresponding human T-ALL immunophenotypes are indicated. DN = Double Negative, DP = Double Positive, NK = Natural Killer cells, ETP = Early T-cell progenitors, ▲up-regulation, ▼down-regulation.

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