Table 1 Clinical characteristics of GMALL T-ALL patients with respect to BCL11b expression
Characteristics | BCL11b-low | BCL11b-high | |
|---|---|---|---|
Q1 | Q2-4 | P-value | |
n | 40 | 129 | |
BCL11b expression | |||
Median | 0.1 | 0.8 | |
Range | 0-0.2 | 0.2-12.3 | |
Age | n.s. | ||
15-35 yrs | 27 | 70 | |
36-55 yrs | 13 | 48 | |
56-65 yrs | 0 | 11 | |
Sex | n.s. | ||
Female % | 20% | 26% | |
WBC, × 109/l | 0.01 | ||
<30,000 | 24 | 42 | |
30-100,000 | 10 | 53 | |
>100,000 | 5 | 30 | |
T-ALL subtype | 0.01 | ||
Early n (%) | 17 (42%) | 23 (18%) | |
Mature n (%) | 5 (13%) | 22 (17%) | |
Thymic n (%) | 18 (45%) | 84 (65%) | |
Response to induction therapy | n.s. | ||
CR n (%) | 37 (95%) | 115 (94%) | |
ED n (%) | 1 (3%) | 3 (2%) | |
Failure n (%) | 1 (3%) | 5 (4%) | |