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Table 1 Radiosensitization effects of YM155 on ESCC cells in vitro

From: Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair

 

D0(Mean inactivation dose)

Dq

Surviving fraction (2 Gy)

Sensitization enhancement ratio

Eca109

 

Control

2.74

1.78

0.72

 

YM155 (5 nM)

2.34

0.13

0.44

1.20

YM155 (10 nM)

1.82

0.03

0.34

1.51

TE13

 

Control

1.52

1.97

0.71

 

YM155 (5 nM)

0.98

1.41

0.44

1.55

YM155 (10 nM)

0.88

0.82

0.24

1.73