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Table 2 Abrogation of G2/M checkpoint by YM155 in ESCC cells

From: Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair

  Eca109 TE13
Treatment G1(%) S (%) G2/M (%) G1(%) S (%) G2/M (%)
Control 42.7 26.3 28.0 45.7 27.4 23.9
YM155 51.4 22.2 22.6 59.6 35 7.8
IR 13.6 23.1 62.5 23.4 8.7 66.8
IR + YM155 45.8 14.3 34.7 46.6 13.2 36.4
Treatment G 1 (%) S (%) G 2 /M (%) G 1 (%) S (%) G 2 /M (%)
Control 42.1 43.3 13.9 39.7 39.9 18.7
IR 12.4 25.1 60.0 32.9 21.4 46.0
IR + Noc 2.6 10.8 84.5 5.4 18.8 73.0
IR + YM155 36.8 31.2 28.9 43.5 18.2 35.9
IR + YM155 + Noc 20.7 36.0 41.4 32.1 11.2 55.9