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Table 3 Radiosensitization effects of YM155 on Eca109 xenograft mouse model

From: Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair

Treatment Doubling time (days) Absolute growth delay (days)a Normalized growth delay (days)b Enhancement factor
Control 5.7 ± 0.5 0   
IR 8.0 ± 2.0 2.3 (8.0-5.7)   
YM155 9.0 ± 1.6 3.3 (9.0-5.7)   
IR + YM155 17.6 ± 6.5 11.9 (17.6-5.7) 8.6 (11.9-3.3) 3.75 (8.6/2.3)
  1. aAbsolute growth delay, the doubling tumor time of treatment group minus that of control group; bNormalized growth delay, the time of absolute growth delay of tumor in IR combined with YM155 group minus that of YM155 group.