Table 2 Univariate and multivariate Cox regression analyses FENDRR for DFS or OS of patients in study cohort (n = 158)

Univariate analysis

Age (<50 years vs. >50 years)

0.935

0.618-1.415

0.752

0.954

0.599-1.520

0.843

Gender (male vs. female)

0.805

0.525-1.233

0.318

0.771

0.475-1.252

0.293

Location (Distal vs. Middle + Proximal)

0.827

0.546-1.254

0.372

0.714

0.448-1.138

0.157

Tumor size ( >5 cm vs. <5 cm )

1.392

0.917-2.113

0.120

1.236

0.975-1.565

0.079

Histologic differentiation(Well + Moderately vs. Poorly + Undifferentiated)

1.264

0.826-1.933

0.281

1.518

0.932-2.474

0.094

Invasion depth (T1 + T2 vs.T3 + T4)

1.306

0.863-1.978

0.207

1.323

0.829-2.111

0.240

TNM stage (I + II vs. III + IV)

0.470

0.308-0.717

<0.001*

0.405

0.251-0.653

<0.001*

Lymphatic metastasis (No vs. Yes)

0.617

0.404-0.924

0.025*

0.624

0.389-1.000

0.05*

Regional lymph nodes (PN2+ PN3 vs. PN0+ PN1)

0.626

0.410-0.954

0.029*

0.570

0.356-0.912

0.019*

Distant metastasis (No vs. Yes)

0.493

0.279-0.874

0.015*

0.523

0.275-0.996

0.049*

Expression of FENDRR (High vs. Low)

0.563

0.370-0.856

0.007*

0.539

0.337-0.862

0.010*

Multivariate analysis

TNM stage (I + II vs. III + IV)

0.566

0.333-0.962

0.035*

0.458

0.253-0.828

0.010*

Lymphatic metastasis (No vs. Yes)

0.740

0.408-1.342

0.322

0.913

0.458-1.822

0.797

Regional lymph nodes (PN0+ PN1vs. PN2+ PN3)

0.658

0.338-1.283

0.220

0.779

0.363-1.674

0.522

Distant metastasis (No vs. Yes)

0.577

0.298-1.117

0.103

0.672

0.320-1.411

0.294

Expression of FENDRR (High vs. Low)

0.555

0.344-0.897

0.016*

0.569

0.321-0.960

0.042*