Figure 8
From: Highly efficient, In-vivo Fas-mediated Apoptosis of B-cell Lymphoma by Hexameric CTLA4-FasL
Schematic model of the CTLA4-FasL homo-hexamer. Monomer represents one domain of the CTLA-4 connected to one domain of the FasL. Trimer is composed of the FasL trimer and three domains of the CTLA-4, while two of them are connected by a disulfige bridge. Two CTLA4-FasL trimers may form a homo-hexamer, made of dimer of trimmers or trimer of dimers, resulting in a shift towards a small fraction of a dodecamer state.