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Table 1 CTLA4-FasL or His 6 -CTLA4-FasL cytotoxic effect on different malignant and non-malignant human cell-lines

From: Highly efficient, In-vivo Fas-mediated Apoptosis of B-cell Lymphoma by Hexameric CTLA4-FasL

Cell-line type Cell-line Killing effect ~EC50 Incubation time
Human liver cancer Hep-G2 Positive 1.0 nM 24 hours
SK-Hep1 Positive 1.5 nM 24 hours
Huh-7 Negative >>120 nM 48 hours
Human liver cells (non-malignant) FH-B Negative 100 nM 24 hours
Human kidney cancer A498 Positive 1.0 nM 24 hours
Caki-1 Positive 2.0 nM 24 hours
786-0 Positive 1.0 nM 24 hours
Human kidney cells (non-malignant) PCS-400-010 Negative 100 nM 24 hours
PCS-400-011 Negative 100 nM 24 hours
Human lymphoma (B cells) Raji Positive 0.02 nM 24 hours
JY Positive 0.04 nM 24 hours
Human multiple myeloma RPMI 8226 Negative >120 nM 24 hours
Human leukemia HL-60 Negative >>120 nM 24 hours
  1. Different human cell lines were incubated with different concentrations of CTLA4-FasL for 24 or 48 h. Cell viability was tested using the MTS assay.