Figure 4
LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promoted human osteosarcoma SAOS-2 cells motility relative to empty vector. (A) Transwell migration assay. Both the LRP1-SNRNP25 and KCNMB4-CCND3 fusions significantly promoted cell migration of SAOS-2 cells. (B) Transwell invasion assay. While the LRP1-SNRNP25 promoted invasion of SAOS-2 cells significantly, KCNMB4-CCND3 fusions did not significantly promote cell invasion. (C) Wound healing assay showed that both fusions accelerated the osteosarcoma cell migration.