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Table 1 Clinical characteristics and laboratory variables

From: CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia

No.

Diagnosis

Gender/Age

Hb (g/L)

WBC (×109/L)

ANC (×109/L)

PLT (×109/L)

Spleen (cm,LCM)

Karyotypes

CSF3R

SETBP1

CALR

JAK2V617F

Treatment

Survival (month)

1

CNL

M/80

120

27.19

25.42

91

3

46,XY,t(1,7) (p32,q11)[10]

T618I

D874N

wt

wt

Hydroxyurea

52

2

CNL

M/64

123

86.83

ND

394

0

46,XY[5]

T618I

D868N

wt

wt

Hydroxyurea

5+

3

CNL

F/77

125

35.68

25.92

351

4

46,XY[20]

T618I

G870S

wt

wt

Hydroxyurea

22+

4

CNL

F/49

104

85.61

79.47

20

6

46,XX[20]

T618I

I871T

wt

wt

Hydroxyurea

13+

5

CNL

M/70

86

146.77

121.82

104

15

ND

T618I

I871T

wt

wt

Hydroxyurea

17

6

CNL

M/43

55

112.65

101.1

98

10

46,XY[5]

T618I

D868N

wt

wt

Hydroxyurea

4+

7

CNL

F/69

102

57.40

40.16

231

6

46,XX[12]

T618I

wt

c.1154-1155insTTGTC

wt

Hydroxyurea

10

8

CNL

M/45

119

32.76

28.73

286

6

46,XY[9]

T618I

wt

wt

wt

Hydroxyurea

32

9

MGUS-CNL

M/46

63

65.30

60.7

101

7

46,XY[2]

wt

wt

wt

wt

Hydroxyurea

6+

10

MGUS-CNL

F/52

121

26.53

19.94

170

3

46,XX[20]

wt

wt

wt

wt

Hydroxyurea

27+

  1. All the parameters in Table 1 were measured at the initial diagnosis in our hospital.
  2. MGUS-CNL: monoclonal gammopathy with uncertain significance associated CNL; Hb: hemoglobin; WBC: White Blood Cell Count; ANC: Absolute Neutrophil Count; PLT: Platelet Count; Spleen (cm): Spleen size under left costa. ND: not done.