Figure 1
From: Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agents
Mechanism of action for selective inhibitors of nuclear transportation. In the nucleus, RanGTP and cargo (tumor suppressors, pro-apoptotic proteins, etc.) form a complex with CRM1/XPO1. This complex is exported through the nuclear pore complex (NPC) to the cytoplasm. CRM1 is then recycled back to the nucleus for another round of export. Selective inhibitors of nuclear export (SINE) binds to CRM1/XPO1 and blocks the protein export, and therefore the cargo proteins are retained in the nucleus, leading to growth inhibition.