Figure 2

In-vivo experiments. (a) Treatment of mice with antagomiR17 inhibits in vivo tumor growth. Plot represents growth curves of tumor-bearing SCID mice treated with either antagomiR17 (5 mice) or scrambled control (5 mice) or saline solution (5 mice) for three times/2 weeks (injections are indicated by arrows). The mass volume of the tumors was measured every two/three days and reported as tumor mass (mg). Dashed, dotted, and solid line indicate mice treated with saline solution, scrambled control, and antagomiR17, respectively. Data represent mean ± s.d. of five biological replicates. *P < 0.05 (antagomiR17 versus scrambled control), **P < 0.01 (antagomiR17 versus scrambled control). (b) AntagomiR17 treatment is associated with increased survival. Kaplan-Meier curves showing percentage of survival probability of tumor-bearing SCID mice treated with antagomiR17 (5 mice) or scrambled control (5 mice) or saline solution (5 mice). Dashed, dotted, and solid line indicate Kaplan-Meier curves of mice treated with saline solution (median OS 52 days), scrambled control (median OS 52 days), and antagomiR17 (median OS 91 days), respectively. The reported P value refers to log-rank test.