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Figure 6 | Journal of Hematology & Oncology

Figure 6

From: c-FLIP is involved in tumor progression of peripheral T-cell lymphoma and targeted by histone deacetylase inhibitors

Figure 6

VPA modulated HDAC1/P50/c-FLIP axis and induced tumor cell apoptosis in a murine xenograft T-lymphoma model. A, The tumor growth curve of the Control group and the VPA group (0.4%w/v in the drinking water daily) in murine xenograft model established with subcutaneous injection of Jurkat cells. B, In situ apoptosis of the Control group and the VPA group was assessed by TUNEL assay. *, P < 0.05 comparing with the untreated (Control) group. C, P50 expression of the Control group and the VPA group was detected by western blot. D, HDAC1, c-FLIP, TRAIL and DR5 expression were evaluated by immunohistochemical study in the Control group and the VPA group.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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