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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma

Figure 4

Intratumorally injected immunotoxin BW-2 inhibits growth in HuD-positive H69 SCLC tumor xenografted mice. SCLC tumor xenografted nude mice (n = 6) were treated with one time intratumoral immunotoxin, or an equivalent dose of mAb alone, saporin toxin alone, or saline. A) Tumor size in BW-2 treated mice remained static or actually regressed for ~3 weeks. B) The control mice exhibited rapidly progressive increases in tumor volume and were overwhelmed by large tumor burden as well as metastases.

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