Figure 5

Intratumorally injected BW-2 inhibits tumor growth and prolongs survival in HuD-positive neuroblastoma allografted mice. A) Two weekly doses of intratumoral BW-2 treatment in neuro-2a allografted A/J mice (n = 5) significantly inhibited local tumor growth as compared to PBS treated controls. In BW-2 treated mice, a temporary loss of fur was observed at the injection site while significant local tumor growth was observed in control mice. Major organs in perfused animals were checked for evidence of metastasis. Metastatic tumors were found on the liver, lymph node and adrenal glands of some of the PBS treated animals. B) Significant tumor regression was observed in more than 80% of studied animals receiving BW-2 (P < 0.001).