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Table 1 Identification of subpopulations of healthy BM cells

From: Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations

 

Normal sorted populations of myeloid lineage

Counterparts with FAB AML

 

Granulocyte lineage subpopulations

 

G1

myeloid progenitor

CD117+CD15-CD11b-

AML M1

AML M2

G2

promyelocyte

CD117+CD15+CD11b-

AML M3

AML M2

G3

promyelocyte-myelocyte

CD117-CD13++CD16-

 

G4

myelocyte

CD117-CD13dimCD16-

 
 

Monocyte lineage subpopulations

 

M1

myeloblast

CD34+SSc++HLA DR+CD33-

AML M1-M0

M2

myelo/monoblast

CD34+Ssc++HLA DR+CD33+

AML M2

M3

promonocyte

CD34-FSc and Ssc corresponding to monocytes CD33+CD14-

AML M4 - AML M5a

M4

monocyte

CD34-FSc and Ssc corresponding to monocytes CD33+CD14+

AML M5b

  1. Main characteristics of stages of myeloid lineage differentiation – surface markers and their counterparts with morphological subtypes of AML.