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Figure 3 | Journal of Hematology & Oncology

Figure 3

From: Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/β-catenin signaling pathway

Figure 3

hBM-MSC-induced β-catenin stabilization is essential for the drug resistance of ALCs, and is eliminated by gal-3 knockdown. (A) The transcriptional level of β-catenin in all four cell lines cultured alone or with hBM-MSCs. (B) The expression of β-catenin and gal-3 in ALCs after transfection with gal-3 shRNA or vector, cultured alone or with hBM-MSCs. (C) ALCs, cultured alone or with hBM-MSCs, were pretreated with ICG-001 (5 μM for Reh cells, 10 μM for Jurkat and Kasumi-1) for 30 minutes, then IDA at indicated concentration was added. Apoptosis was measured after exposure to IDA for 48 h.

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