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Table 1 Summary of miRNAs participating in CNS Embryonal Tumors

From: MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown

miRNA miRNA expression pattern Target gene Molecule/gene expression pattern miRNA regulating role with respect to target-molecule/gene miRNA regulating role to MB CNS neoplasm Reference
miR-124 ↓ compared to normal brain tissue CDK6 ↑ compared to normal brain tissue Interacts Suppresses proliferation, not apoptosis MB Pierson J, Hostager B et al. [58]
miR-124 ↓ compared to normal brain tissue SLC16A1 ↑ compared to normal brain tissue Suppression Suppresses proliferation, not apoptosis MB Li KKW, Pang JCS et al. [59]
miR-129 ↓ compared to normal brain tissue CDK6 ↑ compared to normal brain tissue Suppression Suppresses proliferation, not apoptosis MB Wu J, Qian J et al. [61]
miR-125b ↓ compared to normal brain tissue SMO Promote cerebellar tumorigenesis Suppression Suppresses proliferation,/cell cycle MB Ferretti E, De Smaele E et al. [62]
GLI1 Both ↓ ↑/ Promote cerebellar tumorigenesis Suppression Suppresses proliferation/cell cycle MB
miR-324-5p ↓ compared to normal brain tissue SMO Promote cerebellar tumorigenesis Suppression Suppresses proliferation,/cell cycle MB
GLI1 Both ↓ ↑/ Promote cerebellar tumorigenesis Suppression Suppresses proliferation/cell cycle MB
miR-326 ↓ compared to normal brain tissue SMO Promote cerebellar tumorigenesis Suppression Suppresses proliferation,/cell cycle MB
GLI1 Both ↓ ↑/ Promote cerebellar tumorigenesis Suppression Suppresses proliferation/cell cycle MB
miR-199b-5p ↓ in HES1 overexpressing MB HES1 ↑ compared to normal brain tissue Suppression Suppresses proliferation/cell cycle MB Garzia L, Andolfo I et al. [69]
miR-17 ~ 92 ↑ in MB and Embryonal Neural Tissue Sonic Hedgehog signaling (Ptch1, p53, Ink4c, Nmyc) ↑ compared to normal brain tissue Promotion Promotion MB Uziel T, Karginov FV et al. [63] / Northcott PA, Korshunov A et al. [52]
miR-2
miR-19a
miR-20
miR-106a–92
let-7 g ↓ in Classic, Anaplastic, Desmoplastic MB     Distinguishes Types MB Ferretti E, De Smaele E et al. [76]
miR-19a
miR-191 ↑ in Classic, Anaplastic, Desmoplastic MB     Distinguishes Types MB
miR-106b
miR-10b Mixed pattern of expression ERBB2 (ErbB) Both ↓ ↑   Distinguishes between Over- and Underexpressing MBs MB
miR-125b
miR-135a
miR-135b
miR-153
miR-199b
miR-128-1 Mixed pattern of expression CMYC Both ↓ ↑ Distinguishes between Over- and Underexpressing MBs MB
miR-128-2
miR-181b
miR-30b ↑ in MB at 8q24.22-q24.23 KHDRBS3 ↑ compared to normal brain tissue Correlates MB Lu Y, Ryan SL et al. [80]
miR-30d
miR-17 Mixed pattern of expression     Distinguishes between MB tumor tissue and adjacent Normal tissue MB Liu W, Gong YH et al. [81]
miR-99a
miR-100
miR-106b
miR-204
miR-218
miR-29a
miR-29c
miR-128a
miR-379
miR-127-3p
miR-9
miR-9
miR-214
miR-34a ↓ compared to normal brain tissue CMET ↑ compared to normal brain tissue Suppression Suppresses proliferation/cell cycle MB Guessous F, Zhang Y et al. [82]
NOTCH1 ↑ compared to normal brain tissue Suppression Suppresses proliferation/cell cycle MB
MACE-A ↑ compared to normal brain tissue Suppression Enhances Chemosensitivity MB Weeraratne SD, Amani V et al. [84]
TP53 ↓ in MB Indirect promotion MB
miR-128a ↓ compared to normal brain tissue BMI1 ↑ compared to normal brain tissue Suppression Suppresses tumor growth through senescence MB Venkataraman S, Birks D et al. [77]/Venkataraman S, Alimova I et al. [78]
miR-142-5p ↓ compared to normal brain tissue    Promotion Probable tumor enhancement MB Birks D, Barton VN et al. [85]
miR-25
miR-193a ↑ compared to normal tissue ATOH1, MYCN, TRPM3    Differentiation/Proliferation MB Gokhale A, Kunder R et al. [68]
miR-183
miR-224
miR-182
miR-452
miR-204
miR-365
miR-135a
miR-23b
miR-148a
miR-27b
miR-24
miR-146b
miR-335
miR-98
mIR-199a
miR-92
miR-565
miR-135b
miR-193b
let-7c LEMDE1, KHDRBS2, TRPM3,GRM8
miR-135b
miR-193b
miR-7
miR27b
miR-204 ↓ compared to normal brain tissue
miR-153
miR-410
mIR-487b
miR-433
miR-127
miR-21 ↑ compared to normal tissue     Suppression impedes migration MB Grunder E, D’Ambrosio R et al. [73]
miR-128 ↑ compared to normal tissue Musashi1 ↑ compared to normal brain tissue    MB Vo, Qiao et al. [74]
miR-34a
miR-101
miR-138
miR-128
miR-137
miR-183 ~ 96 ~ 182 ↑ compared to normal tissue PI3K/AKT/mTOR ↑ compared to normal brain tissue   Cell survival, proliferation, migration MB Weeraratne SD, Amani V et al. [84]
miR-33b ↓ compared to normal brain tissue CMYC Its absence promotes MB, when expressed represses MB MB Takwi AA, Li Yet al. [79]
miR-383 ↓ compared to normal brain tissue PRDX3 Its absence promotes MB, when expressed represses MB MB Li KK, Pang JC et al. [88]
miR-494 ↑ compared to normal tissue SDC1 promotes angiogenesis MB Asuthkar S, Velpula KK et al. [89]
miR-218 ↓ compared to normal brain tissue SH3GL1 Suppression Cell survival, proliferation, migration MB Shi J, Yang L et al. [90]
miR-193a-3p ↑ compared to normal tissue WNT signaling pathway (CTNNB1, WIF1, DKK2, MYC)   Promotion Cell survival, proliferation, migration MB Kunder R, Jalali R et al. [54]
miR224
miR-148a
miR-23b
miR-365
miR-let-7f-1 ↓ compared to normal brain tissue     regulator of cis-platin resisance MB Pannuru P, Dontula R et al. [92]
miR-31 ↑ compared to normal tissue MCM2 ↑ compared to normal brain tissue Suppression Inhibition of Chromatin remodelling MB Jin Y, Xiong A et al. [91]
miR-517c ↑ compared to normal tissue WNT signaling pathway (API5, BAD, TRADD, SOX11, NR2F1 NKX2-2, FGF13, FGFr3, SALL4) Promotion Cell survival, proliferation, migration PNET Li M, Lee KF et al. [102]
miR-520 g ↑ compared to normal tissue NKX2-2,OLIG1 Promotion
miR-let-7f-1 ↓ compared to normal brain tissue LIN28, IGF/PI3K/mTOR Promotion Cell survival, proliferation, migration PNET Spence T, Perotti C et al. [105]
miR-221 ↑ compared to normal tissue p27Kip1 ↓ in ATRT Suppression Tumor progression ATRT Sredni ST, de Fátima Bonaldo M et al. [111]
miR-222 ↑ compared to normal tissue p27Kip1 ↓ in ATRT     Sredni ST, de Fátima Bonaldo M et al. [111]
miR-517c ↑ compared to normal tissue      ME/ EB Nobusawa S, Yokoo H et al. [109]
miR-520 g ↑ compared to normal tissue     
miR-371 ↑ compared to normal tissue     
miR-372 ↑ compared to normal tissue     
miR-373 ↑ compared to normal tissue     
miR-142-5p ↑ compared to normal tissue      ATRT Birks DK, Barton VN et al. 2010
miR-25
miR-520b
miR-629
mIR-498
miR-373
miR-140 ↓ compared to normal brain tissue      ATRT Birks DK, Barton VN et al. 2010
miR-let-7b
mIR-139
mIR-153
miR-376b
miR-let-7a3 ↓ compared to normal brain tissue HMGA2 ↑ compared to normal brain tissue    ATRT Zhang K1, Gao H et al. [10]
miR-let-7b