MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown

Braoudaki, Maria; Lambrou, George I

doi:10.1186/s13045-014-0101-5

Journal of Hematology & Oncology

Table 1 Summary of miRNAs participating in CNS Embryonal Tumors

From: MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown

miRNA	miRNA expression pattern	Target gene	Molecule/gene expression pattern	miRNA regulating role with respect to target-molecule/gene	miRNA regulating role to MB	CNS neoplasm	Reference
miR-124	↓ compared to normal brain tissue	CDK6	↑ compared to normal brain tissue	Interacts	Suppresses proliferation, not apoptosis	MB	Pierson J, Hostager B et al. [58]
miR-124	↓ compared to normal brain tissue	SLC16A1	↑ compared to normal brain tissue	Suppression	Suppresses proliferation, not apoptosis	MB	Li KKW, Pang JCS et al. [59]
miR-129	↓ compared to normal brain tissue	CDK6	↑ compared to normal brain tissue	Suppression	Suppresses proliferation, not apoptosis	MB	Wu J, Qian J et al. [61]
miR-125b	↓ compared to normal brain tissue	SMO	Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation,/cell cycle	MB	Ferretti E, De Smaele E et al. [62]
miR-125b	↓ compared to normal brain tissue	GLI1	Both ↓ ↑/ Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation/cell cycle	MB
miR-324-5p	↓ compared to normal brain tissue	SMO	Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation,/cell cycle	MB
miR-324-5p	↓ compared to normal brain tissue	GLI1	Both ↓ ↑/ Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation/cell cycle	MB
miR-326	↓ compared to normal brain tissue	SMO	Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation,/cell cycle	MB
miR-326	↓ compared to normal brain tissue	GLI1	Both ↓ ↑/ Promote cerebellar tumorigenesis	Suppression	Suppresses proliferation/cell cycle	MB
miR-199b-5p	↓ in HES1 overexpressing MB	HES1	↑ compared to normal brain tissue	Suppression	Suppresses proliferation/cell cycle	MB	Garzia L, Andolfo I et al. [69]
miR-17 ~ 92	↑ in MB and Embryonal Neural Tissue	Sonic Hedgehog signaling (Ptch1, p53, Ink4c, Nmyc)	↑ compared to normal brain tissue	Promotion	Promotion	MB	Uziel T, Karginov FV et al. [63] / Northcott PA, Korshunov A et al. [52]
miR-2
miR-19a
miR-20
miR-106a–92
let-7 g	↓ in Classic, Anaplastic, Desmoplastic MB				Distinguishes Types	MB	Ferretti E, De Smaele E et al. [76]
miR-19a	↓ in Classic, Anaplastic, Desmoplastic MB				Distinguishes Types	MB
miR-191	↑ in Classic, Anaplastic, Desmoplastic MB				Distinguishes Types	MB
miR-106b	↑ in Classic, Anaplastic, Desmoplastic MB				Distinguishes Types	MB
miR-10b	Mixed pattern of expression	ERBB2 (ErbB)	Both ↓ ↑		Distinguishes between Over- and Underexpressing MBs	MB
miR-125b
miR-135a
miR-135b
miR-153
miR-199b
miR-128-1	Mixed pattern of expression	CMYC	Both ↓ ↑		Distinguishes between Over- and Underexpressing MBs	MB
miR-128-2
miR-181b
miR-30b	↑ in MB at 8q24.22-q24.23	KHDRBS3	↑ compared to normal brain tissue		Correlates	MB	Lu Y, Ryan SL et al. [80]
miR-30d	↑ in MB at 8q24.22-q24.23	KHDRBS3	↑ compared to normal brain tissue		Correlates	MB	Lu Y, Ryan SL et al. [80]
miR-17	Mixed pattern of expression				Distinguishes between MB tumor tissue and adjacent Normal tissue	MB	Liu W, Gong YH et al. [81]
miR-99a
miR-100
miR-106b
miR-204
miR-218
miR-29a
miR-29c
miR-128a
miR-379
miR-127-3p
miR-9
miR-9
miR-214
miR-34a	↓ compared to normal brain tissue	CMET	↑ compared to normal brain tissue	Suppression	Suppresses proliferation/cell cycle	MB	Guessous F, Zhang Y et al. [82]
		NOTCH1	↑ compared to normal brain tissue	Suppression	Suppresses proliferation/cell cycle	MB	Guessous F, Zhang Y et al. [82]
		MACE-A	↑ compared to normal brain tissue	Suppression	Enhances Chemosensitivity	MB	Weeraratne SD, Amani V et al. [84]
		TP53	↓ in MB	Indirect promotion	Enhances Chemosensitivity	MB	Weeraratne SD, Amani V et al. [84]
miR-128a	↓ compared to normal brain tissue	BMI1	↑ compared to normal brain tissue	Suppression	Suppresses tumor growth through senescence	MB	Venkataraman S, Birks D et al. [77]/Venkataraman S, Alimova I et al. [78]
miR-142-5p	↓ compared to normal brain tissue			Promotion	Probable tumor enhancement	MB	Birks D, Barton VN et al. [85]
miR-25	↓ compared to normal brain tissue			Promotion	Probable tumor enhancement	MB	Birks D, Barton VN et al. [85]
miR-193a	↑ compared to normal tissue	ATOH1, MYCN, TRPM3			Differentiation/Proliferation	MB	Gokhale A, Kunder R et al. [68]
miR-183
miR-224
miR-182
miR-452
miR-204
miR-365
miR-135a
miR-23b
miR-148a
miR-27b
miR-24
miR-146b
miR-335
miR-98
mIR-199a
miR-92
miR-565
miR-135b
miR-193b
let-7c		LEMDE1, KHDRBS2, TRPM3,GRM8
miR-135b
miR-193b
miR-7
miR27b
miR-204	↓ compared to normal brain tissue
miR-153
miR-410
mIR-487b
miR-433
miR-127
miR-21	↑ compared to normal tissue				Suppression impedes migration	MB	Grunder E, D’Ambrosio R et al. [73]
miR-128	↑ compared to normal tissue	Musashi1	↑ compared to normal brain tissue			MB	Vo, Qiao et al. [74]
miR-34a
miR-101
miR-138
miR-128
miR-137
miR-183 ~ 96 ~ 182	↑ compared to normal tissue	PI3K/AKT/mTOR	↑ compared to normal brain tissue		Cell survival, proliferation, migration	MB	Weeraratne SD, Amani V et al. [84]
miR-33b	↓ compared to normal brain tissue	CMYC			Its absence promotes MB, when expressed represses MB	MB	Takwi AA, Li Yet al. [79]
miR-383	↓ compared to normal brain tissue	PRDX3			Its absence promotes MB, when expressed represses MB	MB	Li KK, Pang JC et al. [88]
miR-494	↑ compared to normal tissue	SDC1			promotes angiogenesis	MB	Asuthkar S, Velpula KK et al. [89]
miR-218	↓ compared to normal brain tissue	SH3GL1		Suppression	Cell survival, proliferation, migration	MB	Shi J, Yang L et al. [90]
miR-193a-3p	↑ compared to normal tissue	WNT signaling pathway (CTNNB1, WIF1, DKK2, MYC)		Promotion	Cell survival, proliferation, migration	MB	Kunder R, Jalali R et al. [54]
miR224
miR-148a
miR-23b
miR-365
miR-let-7f-1	↓ compared to normal brain tissue				regulator of cis-platin resisance	MB	Pannuru P, Dontula R et al. [92]
miR-31	↑ compared to normal tissue	MCM2	↑ compared to normal brain tissue	Suppression	Inhibition of Chromatin remodelling	MB	Jin Y, Xiong A et al. [91]
miR-517c	↑ compared to normal tissue	WNT signaling pathway (API5, BAD, TRADD, SOX11, NR2F1 NKX2-2, FGF13, FGFr3, SALL4)		Promotion	Cell survival, proliferation, migration	PNET	Li M, Lee KF et al. [102]
miR-520 g	↑ compared to normal tissue	NKX2-2,OLIG1		Promotion	Cell survival, proliferation, migration	PNET	Li M, Lee KF et al. [102]
miR-let-7f-1	↓ compared to normal brain tissue	LIN28, IGF/PI3K/mTOR		Promotion	Cell survival, proliferation, migration	PNET	Spence T, Perotti C et al. [105]
miR-221	↑ compared to normal tissue	p27^Kip1	↓ in ATRT	Suppression	Tumor progression	ATRT	Sredni ST, de Fátima Bonaldo M et al. [111]
miR-222	↑ compared to normal tissue	p27^Kip1	↓ in ATRT				Sredni ST, de Fátima Bonaldo M et al. [111]
miR-517c	↑ compared to normal tissue					ME/ EB	Nobusawa S, Yokoo H et al. [109]
miR-520 g	↑ compared to normal tissue
miR-371	↑ compared to normal tissue
miR-372	↑ compared to normal tissue
miR-373	↑ compared to normal tissue
miR-142-5p	↑ compared to normal tissue					ATRT	Birks DK, Barton VN et al. 2010
miR-25
miR-520b
miR-629
mIR-498
miR-373
miR-140	↓ compared to normal brain tissue					ATRT	Birks DK, Barton VN et al. 2010
miR-let-7b
mIR-139
mIR-153
miR-376b
miR-let-7a3	↓ compared to normal brain tissue	HMGA2	↑ compared to normal brain tissue			ATRT	Zhang K1, Gao H et al. [10]
miR-let-7b	↓ compared to normal brain tissue	HMGA2	↑ compared to normal brain tissue			ATRT	Zhang K1, Gao H et al. [10]

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