From: MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown
miRNA | miRNA expression pattern | Target gene | Molecule/gene expression pattern | miRNA regulating role with respect to target-molecule/gene | miRNA regulating role to MB | CNS neoplasm | Reference |
---|---|---|---|---|---|---|---|
miR-124 | ↓ compared to normal brain tissue | CDK6 | ↑ compared to normal brain tissue | Interacts | Suppresses proliferation, not apoptosis | MB | Pierson J, Hostager B et al. [58] |
miR-124 | ↓ compared to normal brain tissue | SLC16A1 | ↑ compared to normal brain tissue | Suppression | Suppresses proliferation, not apoptosis | MB | Li KKW, Pang JCS et al. [59] |
miR-129 | ↓ compared to normal brain tissue | CDK6 | ↑ compared to normal brain tissue | Suppression | Suppresses proliferation, not apoptosis | MB | Wu J, Qian J et al. [61] |
miR-125b | ↓ compared to normal brain tissue | SMO | Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation,/cell cycle | MB | Ferretti E, De Smaele E et al. [62] |
GLI1 | Both ↓ ↑/ Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation/cell cycle | MB | |||
miR-324-5p | ↓ compared to normal brain tissue | SMO | Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation,/cell cycle | MB | |
GLI1 | Both ↓ ↑/ Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation/cell cycle | MB | |||
miR-326 | ↓ compared to normal brain tissue | SMO | Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation,/cell cycle | MB | |
GLI1 | Both ↓ ↑/ Promote cerebellar tumorigenesis | Suppression | Suppresses proliferation/cell cycle | MB | |||
miR-199b-5p | ↓ in HES1 overexpressing MB | HES1 | ↑ compared to normal brain tissue | Suppression | Suppresses proliferation/cell cycle | MB | Garzia L, Andolfo I et al. [69] |
miR-17 ~ 92 | ↑ in MB and Embryonal Neural Tissue | Sonic Hedgehog signaling (Ptch1, p53, Ink4c, Nmyc) | ↑ compared to normal brain tissue | Promotion | Promotion | MB | Uziel T, Karginov FV et al. [63] / Northcott PA, Korshunov A et al. [52] |
miR-2 | |||||||
miR-19a | |||||||
miR-20 | |||||||
miR-106a–92 | |||||||
let-7 g | ↓ in Classic, Anaplastic, Desmoplastic MB |  |  |  | Distinguishes Types | MB | Ferretti E, De Smaele E et al. [76] |
miR-19a | |||||||
miR-191 | ↑ in Classic, Anaplastic, Desmoplastic MB |  |  |  | Distinguishes Types | MB | |
miR-106b | |||||||
miR-10b | Mixed pattern of expression | ERBB2 (ErbB) | Both ↓ ↑ |  | Distinguishes between Over- and Underexpressing MBs | MB | |
miR-125b | |||||||
miR-135a | |||||||
miR-135b | |||||||
miR-153 | |||||||
miR-199b | |||||||
miR-128-1 | Mixed pattern of expression | CMYC | Both ↓ ↑ | Distinguishes between Over- and Underexpressing MBs | MB | ||
miR-128-2 | |||||||
miR-181b | |||||||
miR-30b | ↑ in MB at 8q24.22-q24.23 | KHDRBS3 | ↑ compared to normal brain tissue | Correlates | MB | Lu Y, Ryan SL et al. [80] | |
miR-30d | |||||||
miR-17 | Mixed pattern of expression | Â | Â | Â | Distinguishes between MB tumor tissue and adjacent Normal tissue | MB | Liu W, Gong YH et al. [81] |
miR-99a | |||||||
miR-100 | |||||||
miR-106b | |||||||
miR-204 | |||||||
miR-218 | |||||||
miR-29a | |||||||
miR-29c | |||||||
miR-128a | |||||||
miR-379 | |||||||
miR-127-3p | |||||||
miR-9 | |||||||
miR-9 | |||||||
miR-214 | |||||||
miR-34a | ↓ compared to normal brain tissue | CMET | ↑ compared to normal brain tissue | Suppression | Suppresses proliferation/cell cycle | MB | Guessous F, Zhang Y et al. [82] |
NOTCH1 | ↑ compared to normal brain tissue | Suppression | Suppresses proliferation/cell cycle | MB | |||
MACE-A | ↑ compared to normal brain tissue | Suppression | Enhances Chemosensitivity | MB | Weeraratne SD, Amani V et al. [84] | ||
TP53 | ↓ in MB | Indirect promotion | MB | ||||
miR-128a | ↓ compared to normal brain tissue | BMI1 | ↑ compared to normal brain tissue | Suppression | Suppresses tumor growth through senescence | MB | Venkataraman S, Birks D et al. [77]/Venkataraman S, Alimova I et al. [78] |
miR-142-5p | ↓ compared to normal brain tissue |  |  | Promotion | Probable tumor enhancement | MB | Birks D, Barton VN et al. [85] |
miR-25 | |||||||
miR-193a | ↑ compared to normal tissue | ATOH1, MYCN, TRPM3 |  |  | Differentiation/Proliferation | MB | Gokhale A, Kunder R et al. [68] |
miR-183 | |||||||
miR-224 | |||||||
miR-182 | |||||||
miR-452 | |||||||
miR-204 | |||||||
miR-365 | |||||||
miR-135a | |||||||
miR-23b | |||||||
miR-148a | |||||||
miR-27b | |||||||
miR-24 | |||||||
miR-146b | |||||||
miR-335 | |||||||
miR-98 | |||||||
mIR-199a | |||||||
miR-92 | |||||||
miR-565 | |||||||
miR-135b | |||||||
miR-193b | |||||||
let-7c | LEMDE1, KHDRBS2, TRPM3,GRM8 | ||||||
miR-135b | |||||||
miR-193b | |||||||
miR-7 | |||||||
miR27b | |||||||
miR-204 | ↓ compared to normal brain tissue | ||||||
miR-153 | |||||||
miR-410 | |||||||
mIR-487b | |||||||
miR-433 | |||||||
miR-127 | |||||||
miR-21 | ↑ compared to normal tissue |  |  |  | Suppression impedes migration | MB | Grunder E, D’Ambrosio R et al. [73] |
miR-128 | ↑ compared to normal tissue | Musashi1 | ↑ compared to normal brain tissue |  |  | MB | Vo, Qiao et al. [74] |
miR-34a | |||||||
miR-101 | |||||||
miR-138 | |||||||
miR-128 | |||||||
miR-137 | |||||||
miR-183 ~ 96 ~ 182 | ↑ compared to normal tissue | PI3K/AKT/mTOR | ↑ compared to normal brain tissue |  | Cell survival, proliferation, migration | MB | Weeraratne SD, Amani V et al. [84] |
miR-33b | ↓ compared to normal brain tissue | CMYC | Its absence promotes MB, when expressed represses MB | MB | Takwi AA, Li Yet al. [79] | ||
miR-383 | ↓ compared to normal brain tissue | PRDX3 | Its absence promotes MB, when expressed represses MB | MB | Li KK, Pang JC et al. [88] | ||
miR-494 | ↑ compared to normal tissue | SDC1 | promotes angiogenesis | MB | Asuthkar S, Velpula KK et al. [89] | ||
miR-218 | ↓ compared to normal brain tissue | SH3GL1 | Suppression | Cell survival, proliferation, migration | MB | Shi J, Yang L et al. [90] | |
miR-193a-3p | ↑ compared to normal tissue | WNT signaling pathway (CTNNB1, WIF1, DKK2, MYC) |  | Promotion | Cell survival, proliferation, migration | MB | Kunder R, Jalali R et al. [54] |
miR224 | |||||||
miR-148a | |||||||
miR-23b | |||||||
miR-365 | |||||||
miR-let-7f-1 | ↓ compared to normal brain tissue |  |  |  | regulator of cis-platin resisance | MB | Pannuru P, Dontula R et al. [92] |
miR-31 | ↑ compared to normal tissue | MCM2 | ↑ compared to normal brain tissue | Suppression | Inhibition of Chromatin remodelling | MB | Jin Y, Xiong A et al. [91] |
miR-517c | ↑ compared to normal tissue | WNT signaling pathway (API5, BAD, TRADD, SOX11, NR2F1 NKX2-2, FGF13, FGFr3, SALL4) | Promotion | Cell survival, proliferation, migration | PNET | Li M, Lee KF et al. [102] | |
miR-520 g | ↑ compared to normal tissue | NKX2-2,OLIG1 | Promotion | ||||
miR-let-7f-1 | ↓ compared to normal brain tissue | LIN28, IGF/PI3K/mTOR | Promotion | Cell survival, proliferation, migration | PNET | Spence T, Perotti C et al. [105] | |
miR-221 | ↑ compared to normal tissue | p27Kip1 | ↓ in ATRT | Suppression | Tumor progression | ATRT | Sredni ST, de Fátima Bonaldo M et al. [111] |
miR-222 | ↑ compared to normal tissue | p27Kip1 | ↓ in ATRT |  |  |  | Sredni ST, de Fátima Bonaldo M et al. [111] |
miR-517c | ↑ compared to normal tissue |  |  |  |  | ME/ EB | Nobusawa S, Yokoo H et al. [109] |
miR-520 g | ↑ compared to normal tissue |  |  |  |  | ||
miR-371 | ↑ compared to normal tissue |  |  |  |  | ||
miR-372 | ↑ compared to normal tissue |  |  |  |  | ||
miR-373 | ↑ compared to normal tissue |  |  |  |  | ||
miR-142-5p | ↑ compared to normal tissue |  |  |  |  | ATRT | Birks DK, Barton VN et al. 2010 |
miR-25 | |||||||
miR-520b | |||||||
miR-629 | |||||||
mIR-498 | |||||||
miR-373 | |||||||
miR-140 | ↓ compared to normal brain tissue |  |  |  |  | ATRT | Birks DK, Barton VN et al. 2010 |
miR-let-7b | |||||||
mIR-139 | |||||||
mIR-153 | |||||||
miR-376b | |||||||
miR-let-7a3 | ↓ compared to normal brain tissue | HMGA2 | ↑ compared to normal brain tissue |  |  | ATRT | Zhang K1, Gao H et al. [10] |
miR-let-7b |