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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells

Figure 1

Reduced HSC in Angptl7 −/− mice. (a) Characterization of multiple hematopoietic lineages in BM. The major lineages of hematopoietic cells in BM in Angptl7 −/− Angptl7 +/− and Angptl7 +/+ mice were quantitated by flow cytometry analysis as erythroid cells (Ter119), myeloid cells (Ly6g and CD11b), T cells (CD3e) and B cells (CD19). Data represent the means +/− s.e.m (n = 5 for each group). (b, c) Comparison of the frequencies (b) and number (c) of Lin-Mac-1 + CD4- population in the fetal liver of Angptl7 −/− Angptl7 +/− and Angptl7 +/+ mice. Data represent the means +/− s.e.m (n = 10 for each group). *P < 0.05 versus Angptl7 −/− group for Angptl7 +/− and Angptl7 +/+. (d, e) Comparison of the frequencies (d) and number (e) of LSK population in the BM of Angptl7 −/− Angptl7 +/− and Angptl7 +/+ mice. Data represent the means +/− s.e.m (n = 6 for each group). *P < 0.05 versus Angptl7 −/− group for Angptl7 +/− and Angptl7 +/+ group. (f, g) Comparison of the frequencies (left) and number (right) of LT-HSCs in the BM of Angptl7 −/− Angptl7 +/− and Angptl7 +/+ mice. Data represent the means +/− s.e.m (n = 5 for each group). *P < 0.05 versus Angptl7 −/− group for Angptl7 +/− and Angptl7 +/+ group. (h) The colony numbers of CFU assays obtained from BM of Angptl7 −/− Angptl7 +/− and Angptl7 +/+ mice. Data represent the means +/− s.e.m (n = 3). *P < 0.05 versus bar 7 for bar 9.

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