Representative staining patterns of Notch1, N1-ICD-V1754 and heterogeneous tumor cell proliferation (Ki67) in NSCLC tumor tissues. Notch1, N1-ICD-V1754 and Ki67 in a case of undifferentiated carcinoma of the lung, showing high level of membranous/cytoplasmic/nuclear Notch1 expression (A2), nuclear N1-ICD-V1754 (A3), and Ki67 labeling (A4). Notch1, N1-ICD-V1754 and Ki67 in a case of squamous cell carcinoma of the lung, displaying high level of cytoplasmic/membranous/nuclear Notch1staining (B2), heterogeneous N1-ICD-V1754 (B3), and Ki67 proliferation (B4). Notch1, N1-ICD-V1754 and Ki67 in a case of adenocarcinoma of the lung, exhibiting cytoplasmic/membranous Notch1 signal (C2) and some nuclear N1-ICD-V1754 staining on the right (C3), and Ki67 expression (C4). HE staining of undifferentiated carcinoma, squamous cell carcinoma and adenocarcinoma of the lung (A1, B1, and C1). Magnifications x200.