Figure 3

IGF-IR deficiency alters BCR/ABL leukemia fates. (A) Representative flow cytometry plots showing CML, T-ALL, and B-ALL cells in mice transplanted with WT or IGF-IR-null BCR/ABL cells. (B) Cytospin staining of CML and ALL in mice transplanted with WT or IGF-IR-null BCR/ABL cells. (C) Percentages of different types of leukemia developed by mice transplanted with BCR/ABL-infected WT or IGF-IR-null hematopoietic progenitors. (D) Survival curves of mice receiving BCR/ABL-infected WT or IGF-IR-null hematopoietic progenitors that developed different types of leukemia (n = 15).