Skip to main content

Table 1 The main genes up-regulated in NGDN knock-down leukemia cells K562/A02-KD compared with negative control cells K562/A02-NC (n = 3, P< 0.05)

From: High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs

Category

Gene name

Relative mRNA expression level (K562/A02-KD/K562/A02-NC)

Extracellular signal gene

IGF1

1.7

IGF1R

1.7

Signal transduction pathway gene

mTOR

7.9

Akt

13.7

PDPK1

3.0

TSC1

1.9

PKC

1.7

IL1R1

2.6

TOLLIP

1.8

MAPK3

1.5

NF-κB2

2.4

STAT2

2.1

Transcription factor gene

NFAT

2.9

ELK1

2.5

E2F1

1.5

HSF1

1.6

Cell invasion and metastasis-related gene

CTNN

2.9

FN1

2.1

ITGAM

1.5

VIM

1.7

Oncogene

MYC

1.5

Ras

1.5

JUN

3.6

  1. IGF1 insulin-like growth factor 1, IGF1R receptor of insulin-like growth factor 1, mTOR mammalian target of rapamycin, Akt protein kinase B, PDPK1 3-phosphoinositide-dependent protein kinase-1, TSC1 tuberous sclerosis complex 1, PKC protein kinase C, IL1R1 receptor 1 of interleukin 1, TOLLIP toll interacting protein, MAPK3 mitogen-activated protein kinase 3, NF-κB2 Nuclear transcription factor-kappa B 2, STAT2 signal transducer and activator of transcription 2, NFAT nuclear factor of activated T cells, ELK1 ETS-like gene 1, E2F1 E2F transcription factor 1, HSF1 heat shock factor 1, CTNN catenin, FN1 fibronectin 1, ITGAM integrin alpha-M, VIM vimentin.