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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Transfer of microRNAs by extracellular membrane microvesicles: a nascent crosstalk model in tumor pathogenesis, especially tumor cell-microenvironment interactions

Figure 1

A new working model of EMV-mediated miRNA transfer in tumor. As crosstalk mediators, extracellular membrane microvesicles (EMVs), which are derived from cancer cells, carry the selective microRNAs to exert the direct effects into (A) the homological cancer cells to promote malignant transformation; (B) the neighboring cells, such as endothelial cells, to construct the tumor microenvironment; and (C) peripheral circulation to be used as novel diagnostic biomarkers and prognostic monitoring. (D) Meanwhile, cancer cells can also be influenced by absorbing miRNA-containing EMVs from the adjacent nonmalignant cells. MV, microvesicle; miRNA, microRNA.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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