Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

Table 2 Phenotype of CSC-enriched fractions of neoplastic cells in solid tumors ^a

Neoplasm	Phenotype of CSC-rich cell fraction	Reference
Breast cancer	CD326+/CD45−/CD44+/CD24−	[40]
	CD44+/CD49f+/CD133+	[92]
	CD326+/CD44+/CD47+/MET+	[93]
	CD29f
Gastric cancer	CD326+/CD44+	[94]
	CD49f+	[95]
	CD90+	[96]
	LGR5^b+	[97]
	CD44+	[98]
Colon cancer	CD326+/CD44+/CD166+	[99]
	CD44+/CD49f+/CD133+	[100]
	LGR5^b+	[101]
	CD133+	[47]
SCLC	CD133+	[102]
NSCLC	CD133+	[103]
Pancreatic cancer	CD44+/CD24+/CD326+	[43]
	CD133+/CXCR4+	[39]
HCC	CD326	[104]
	CD133+	[105]
	CD44+/CD90+	[44]
Glioblastoma	CD133+	[42]
	CD15+/CD133+	[106]
	CD15+/CD133+	[106]
	CD133+/SSEA-1+	[107]
Ewing’s sarcoma	CD133+	[108]
Osteosarcoma	CD133+	[109]
	CD117+/STRO-1+	[110]
	CD271+	[111]
Ovarian cancer	CD24+/CD44+/CD326+	[112]
	CD44+/CD117+	[113]
	CD133+	[114]
Prostate cancer	CD44+/CD49f/CD326+	[115]
	CD44+/CD24−	[116]
	CD44+/CD133+	[117]
Melanoma	CD271+	[118]
	ABCB5+	[119]
	EPOR+	[120]

NSC, neoplastic stem cells; LGR5, Leucine-rich repeat-containing G-protein coupled receptor 5; SCLC, small cell lung cancer; n.k., not known; NSCL, non-small cell lung cancer; HCC, hepatocellular carcionoma; EPOR, erythropoietin receptor. ^aExpression of NSC markers refers to primary human cells tested in xenotransplantation assays and/or in a sphere-formation assay. ^bLGR5 is not detectable on human NSC by flow cytometry.

ISSN: 1756-8722