Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

Table 4 Cytokine/chemokine receptors detectable on neoplastic stem cells (NSC)

Malignancy	Cytokine receptors expressed on NSC
AML	IL-2RA [154], IL-3RA [155], G-CSFR [156], FLT3 [157], SCFR/KIT [158], CXCR4 [159]
MDS	G-CSFR [160], SCFR/KIT, CXCR4 [161]
MPN	G-CSFR [160], SCFR/KIT [162], CXCR4 [163]
Ph + CML	IL-2RA [83], IL-3RA [17], G-CSFR [160], GM-CSFR [164], SCFR/KIT [165], IL-1RAP [87], CXCR4 [166]
Ph + ALL	IL-2RA [167], IL-3RA [168], CXCR4 [169]
Myeloma	CXCR4 [170]
Breast cancer	EGFR [171], ERBB2/Her2 [172], FGFR2 [173], TGFßR [174], MET [93]
Gastric cancer	EGFR [175], ERBB2/Her2 [176]
Colon cancer	EGFR [177], CXCR4 [178], IGF1R [179], TGFßR [180]
SCLC	EGFR [181]
Pancreatic cancer	EGFR [182], CXCR4 [39]
HCC	EGFR, IGF1R [183]
Glioblastoma	EGFR [184], PDGFRB [185], CXCR4 [186], TGFßR [187], MET [188]
Ovarian cancer	EGFR [189], ERBB2/Her2 [190], IGF1R, TGFßR [191]
Prostate cancer	CXCR4 [192]
Melanoma	CXCR1 [193], EPOR [120]

AML, acute myeloid leukemia; IL, interleukin; G-CSFR, granulocyte colony-stimulating factor receptor; SCF, stem cell factor receptor; Ph+, Philadelphia chromosome-positive; CML, chronic myeloid leukemia; GM-CSF, granulocyte- macrophage colony-stimulating factor; ALL, acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; EGFR, epidermal growth factor receptor; TGFßR, transforming growth factor ß receptor; IGF1R, insulin-like growth factor 1 receptor; SCLC, small cell lung cancer; NSCL, non-small cell lung cancer; n.k., not known; HCC, hepatocellular carcionoma; PDGFR, platelet-derived growth factor receptor; NGFR, nerve growth factor receptor; EPOR, erythropoietin receptor.

ISSN: 1756-8722