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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

Figure 2

The phenotype of hematopoietic defects is caused by mutation in dnmt1 . (A) Genetic mapping of ldd794 on chromosome 3. The numbers above the SSLP markers indicate the number of recombinants in 1,056 meioses analyzed. Fine mapping using SSLPs narrowed down the region between sslp1 and sslp2 markers. The red asterisk indicates the mutation position within dnmt1 gene. (B) Sequence traces of pooled sibling and pooled dnmt1 mutant cDNAs. A T to A transversion at 2,229th nucleotide resulted in a stop codon in dnmt1 (marked by red asterisk). (C) Sequence result of grandparents. The sequence result indicated that this pair of ldd794 mutants (screened out in ENU project) was heterozygote carrying one mutated allele of dnmt1 (marked by red asterisk). (D) Structure of wild-type and mutant Dnmt1 protein. (E) Synteny analysis of dnmt1.

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