Skip to main content
Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Local administration of a novel Toll-like receptor 7 agonist in combination with doxorubicin induces durable tumouricidal effects in a murine model of T cell lymphoma

Figure 1

SZU-101-activated immune response through TLR7 signalling. (A) SZU-101 induced the activation of TLR7-NF-κB signalling. The solid line indicates the relative inductions by SZU-101 or TNF-α (as positive control) in a HEK-BLUE TLR7-specific reporter system. The dotted line indicates the inductions of SZU-101 or TNF-α in the non-reporter HEK-293 controls (**p < 0.01, one-way ANOVA). (B), (C). The expression of CD69, CD86 and CD80 after SZU-101 stimulation. Splenocytes were collected after 2 or 4 h post SZU-101 treatment and analysed by flow cytometry (**p < 0.01, one-way ANOVA). (D) The induction of systemic cytokines was analysed by ELISA assay. The serums were collected after 2, 4 or 24 h post treatment. Each group in the experiment contained five mice.

Back to article page