Figure 5

The immune response by co-culture of murine lymphocytes with tumour cells. The lymphocytes from long-term surviving mice were co-cultured with EL4 cells at an effector: target ratio of 10:1. (A) The cytokine induction of IFN-γ or IL-6 (IFN-γ production, ++p < 0.05 compared with control; **p < 0.05 compared with other SZU-101 treatments; IL-6, **p < 0.05 compared with SZU-101 i.t.; one-way ANOVA). (B) CTL-mediated cytotoxicity was assayed using the lymphocytes from mice with different treatments (+p < 0.05 compared with control; **p < 0.05 compared with other SZU-101 treatments; one-way ANOVA). Each group in the experiment contained at least six mice.