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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells

Figure 1

Microarray analysis for gene expression profiles of K562 cells after transfection with PPP2R5C-siRNA991. (A) Scatter plots comparing the gene expression profiles of siRNA991 and scrambled control (SC) transfected cells. The yellow dots represent genes undetected in both samples, blue dots represent genes present in both samples, red dots represent upregulated genes, and green dots represent downregulated genes. (B) The Affymetrix data were clustered, and the red and green colors represent the expression levels increased or decreased, respectively, with respect to the average expression across all samples. (C) PI3K/AKT signaling pathway genes differentially expressed in K562 cells after PPP2R5C suppression. (D) JAK/STAT signaling pathways genes differentially expressed in K562 cells after PPP2R5C suppression. (E) Schematic model of the BCR-ABL-mediated BRAF-MEK-FOS-JUN signaling pathway due to PPP2R5C suppression in K562 cells (modified from reference [8]).

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