Table 1 Cell proliferation and apoptosis genes altered after PPP2R5C knockdown in K562 cells in microarray analysis
Gene symbol | NCBI accession | Fold change | Description | Pathway |
|---|---|---|---|---|
BRAF | NM_004333 | −2.24 | v-raf murine sarcoma viral oncogene homolog B1 | MAPK signaling pathway |
MAP2K2 | NM_030662 | −2.39 | mitogen-activated protein kinase kinase 2 | MAPK signaling pathway |
ELK1 | NM_001114123 | −2.65 | ELK1, member of ETS oncogene family | MAPK signaling pathway |
FOS | NM_005252 | −3.12 | FBJ murine osteosarcoma viral oncogene homolog | MAPK signaling pathway |
JUN | NM_002228 | −4.88 | jun proto-oncogene | MAPK signaling pathway |
NFKB2 | NM_001077493 MAPK signaling pathway/AKT signaling pathway | −2.81 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | |
AKT2 | NM_001626 | −2.72 | V-akt murine thymoma viral oncogene homolog 2 | MAPK signaling pathway/AKT signaling pathway |
AKT3 | NM_005465 | −12.47 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | MAPK signaling pathway/AKT signaling pathway |
CRKL | NM_005207 | −2.14 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | MAPK signaling pathway/AKT signaling pathway |
IL6ST | NM_001190981 | −2.13 | interleukin 6 signal transducer (gp130, oncostatin M receptor) | Jak-STAT signaling pathway |
STAT3 | NM_003150 Jak-STAT signaling pathway | −5.08 | signal transducer and activator of transcription 3 (acute-phase response factor) | |
MDM2 | NM_002392 | 2.26 | Mdm2 p53 binding protein homolog | AKT Signaling Pathway/p53Signaling Pathway |
ATM | NM_000051 | −2.30 | ataxia telangiectasia mutated | p53Signaling Pathway |