From: Zebrafish as a model for leukemia and other hematopoietic disorders
Disease model | Gene | Expression | Latency | Penetrance | References |
---|---|---|---|---|---|
AML | Hs RUNX1-ETO | Ubiquitous | Embryonic | 32–41% | [22] |
Ubiquitous - inducible (hs) | Embryonic (induced) | NS | |||
Hs MOZ/TIF2 | Progenitor (spi1) | 14–26 months | 1% | [47] | |
Hs FLT3 | Ubiquitous | Embryonic | NS | [49] | |
Hs NPMc + | Ubiquitous | Embryonic | NS | [51] | |
Mm Mycn | Ubiquitous - inducible (hs) | Embryonic (induced) | F0: 60% F2: 75% | [54] | |
Dr spi1 G242D | Endogenous - hypomorph | 3 days | NS | [57] | |
Dr ddx18 | Knockout | Embryonic | NS | [58] | |
ALL | Mm Myc | Lymphoid (rag2) | F0: 44–52 days F1: 32 days | F0: 5–6% F1: 100% | |
Lymphoid (rag2) - inducible (cre) | 151 days | 13% | [61] | ||
Lymphoid (rag2) - inducible (cre/hs) | T-LBL: 120 days/T-ALL: 261 days | T-LBL: 81%/T-ALL: 100% | |||
Hs MYC | Ubiquitous - inducible (4HT) | 4–5 weeks (induced) | 100% | ||
Dr pten | Knockout | Embryonic | NS | ||
Hs NOTCH1ic | Lymphoid (rag2) | 5 months | 44% | [73] | |
Hs ETV6-RUNX1 | Ubiquitous | 1 year | 3% | [75] | |
Dr etv6-jak2a (ALL) | Ubiquitous/Progenitor (spi1) | Embryonic | 30%/50% | [78] | |
MPD | Dr jak2a V581F | Ubiquitous | Embryonic | NS | [87] |
Dr stat5 H298R/N714F | Ubiquitous | Embryonic | NS | [88] | |
Dr etv6-jak2a (CML) | Ubiquitous/Progenitor (spi1) | Embryonic | 30%/50% | ||
Hs kRAS G12D | Ubiquitous - inducible (hs + cre) | 34 days (induced) | 8% | [91] | |
Hs HRAS G12V | Endothelial (fli1) | Embryonic | NS | [92] | |
Hs NUP98-HOXA9 | Progenitor (spi1) - inducible (hs + cre) | 19–23 months | 23% | [97] | |
Hs KIT D816V | Ubiquitous | 3–30 months | 48–52 % | [93] | |
MDS | Dr tet2 | Knockout | 2 years | NS | [95] |
Dr hspa9b | Knockout | Embryonic | 80% | [98] |