Zebrafish as a model for leukemia and other hematopoietic disorders

Table 2 List of chemical inhibitors screened in zebrafish models of leukemia

Chemical inhibitors	Mechanism	Gene	References
AML
Trichostatin A	Histone deacetylase inhibitor	RUNX1-ETO	[43]
Nimesulide	COX inhibitor	RUNX1-ETO	[44]
NS-398	COX inhibitor	RUNX1-ETO	[44]
Indomethacin	COX inhibitor	RUNX1-ETO	[44]
Benzodiazepine	RUNX1/CBFβ interactor	RUNX1-ETO	[45]
AC220	Tyrosine kinase inhibitor	FLT3-ITD	[49]
T-ALL
Prephenazine	PP2A activator	MYC	[68]
LY294002	PI3K inhibitor	pten ^−/−	[71]
AG490	JAK2 inhibitor	etv6-jak2a	[78]
MPD
TG101209	JAK2 inhibitor	jak2a ^V581F	[87]
AG490	JAK2 inhibitor	etv6-jak2a	[78]

COX: cyclooxygenase; CBFβ: core binding factor β; PP2A: protein phosphatase 2A; PI3K: phosphoinositide 3-kinase.

ISSN: 1756-8722