TY - JOUR AU - Adams, J. AU - Palombella, V. J. AU - Sausville, E. A. AU - Johnson, J. AU - Destree, A. AU - Lazarus, D. D. PY - 1999 DA - 1999// TI - Proteasome inhibitors: a novel class of potent and effective antitumor agents JO - Cancer Res VL - 59 ID - Adams1999 ER - TY - JOUR AU - Richardson, P. G. AU - Sonneveld, P. AU - Schuster, M. W. AU - Irwin, D. AU - Stadtmauer, E. A. AU - Facon, T. PY - 2005 DA - 2005// TI - Bortezomib or high-dose dexamethasone for relapsed multiple myeloma JO - N Engl J Med VL - 352 UR - https://doi.org/10.1056/NEJMoa043445 DO - 10.1056/NEJMoa043445 ID - Richardson2005 ER - TY - JOUR AU - Richardson, P. G. AU - Sonneveld, P. AU - Schuster, M. AU - Irwin, D. AU - Stadtmauer, E. AU - Facon, T. PY - 2007 DA - 2007// TI - Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial JO - Blood VL - 110 UR - https://doi.org/10.1182/blood-2006-08-036947 DO - 10.1182/blood-2006-08-036947 ID - Richardson2007 ER - TY - JOUR AU - Richardson, P. G. AU - Barlogie, B. AU - Berenson, J. AU - Singhal, S. AU - Jagannath, S. AU - Irwin, D. PY - 2003 DA - 2003// TI - A phase 2 study of bortezomib in relapsed, refractory myeloma JO - N Engl J Med VL - 348 UR - https://doi.org/10.1056/NEJMoa030288 DO - 10.1056/NEJMoa030288 ID - Richardson2003 ER - TY - JOUR AU - Jagannath, S. AU - Barlogie, B. AU - Berenson, J. AU - Siegel, D. AU - Irwin, D. AU - Richardson, P. G. PY - 2004 DA - 2004// TI - A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma JO - Br J Haematol VL - 127 UR - https://doi.org/10.1111/j.1365-2141.2004.05188.x DO - 10.1111/j.1365-2141.2004.05188.x ID - Jagannath2004 ER - TY - JOUR AU - Bartley, T. D. AU - Bogenberger, J. AU - Hunt, P. AU - Li, Y. S. AU - Lu, H. S. AU - Martin, F. PY - 1994 DA - 1994// TI - Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl JO - Cell VL - 77 UR - https://doi.org/10.1016/0092-8674(94)90450-2 DO - 10.1016/0092-8674(94)90450-2 ID - Bartley1994 ER - TY - JOUR AU - Lok, S. AU - Kaushansky, K. AU - Holly, R. D. AU - Kuijper, J. L. AU - Lofton-Day, C. E. AU - Oort, P. J. PY - 1994 DA - 1994// TI - Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo JO - Nature VL - 369 UR - https://doi.org/10.1038/369565a0 DO - 10.1038/369565a0 ID - Lok1994 ER - TY - JOUR AU - Methia, N. AU - Louache, F. AU - Vainchenker, W. AU - Wendling, F. PY - 1993 DA - 1993// TI - Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis JO - Blood VL - 82 ID - Methia1993 ER - TY - JOUR AU - Zeigler, F. AU - Sauvage, F. AU - Widmer, H. AU - Keller, G. AU - Donahue, C. AU - Schreiber, R. PY - 1994 DA - 1994// TI - In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells JO - Blood VL - 84 ID - Zeigler1994 ER - TY - JOUR AU - Borge, O. J. AU - Ramsfjell, V. AU - Veiby, O. P. AU - Murphy, M. J. AU - Lok, S. AU - Jacobsen, S. E. PY - 1996 DA - 1996// TI - Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro JO - Blood VL - 88 ID - Borge1996 ER - TY - JOUR AU - Pestina, T. I. AU - Cleveland, J. L. AU - Yang, C. AU - Zambetti, G. P. AU - Jackson, C. W. PY - 2001 DA - 2001// TI - Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis JO - Blood VL - 98 UR - https://doi.org/10.1182/blood.V98.7.2084 DO - 10.1182/blood.V98.7.2084 ID - Pestina2001 ER - TY - JOUR AU - Vadhan-Raj, S. AU - Verschraegen, C. F. AU - Bueso-Ramos, C. AU - Broxmeyer, H. E. AU - Kudelka, A. P. AU - Freedman, R. S. PY - 2000 DA - 2000// TI - Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer JO - Ann Intern Med VL - 132 UR - https://doi.org/10.7326/0003-4819-132-5-200003070-00005 DO - 10.7326/0003-4819-132-5-200003070-00005 ID - Vadhan-Raj2000 ER - TY - JOUR AU - Jenkins, J. M. AU - Williams, D. AU - Deng, Y. AU - Uhl, J. AU - Kitchen, V. AU - Collins, D. PY - 2007 DA - 2007// TI - Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist JO - Blood VL - 109 UR - https://doi.org/10.1182/blood-2006-11-057968 DO - 10.1182/blood-2006-11-057968 ID - Jenkins2007 ER - TY - JOUR AU - Bussel, J. B. AU - Provan, D. AU - Shamsi, T. AU - Cheng, G. AU - Psaila, B. AU - Kovaleva, L. PY - 2009 DA - 2009// TI - Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial JO - Lancet VL - 373 UR - https://doi.org/10.1016/S0140-6736(09)60402-5 DO - 10.1016/S0140-6736(09)60402-5 ID - Bussel2009 ER - TY - JOUR AU - Bussel, J. B. AU - Cheng, G. AU - Saleh, M. N. AU - Psaila, B. AU - Kovaleva, L. AU - Meddeb, B. PY - 2007 DA - 2007// TI - Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura JO - N Engl J Med VL - 357 UR - https://doi.org/10.1056/NEJMoa073275 DO - 10.1056/NEJMoa073275 ID - Bussel2007 ER - TY - JOUR AU - McHutchison, J. G. AU - Dusheiko, G. AU - Shiffman, M. L. AU - Rodriguez-Torres, M. AU - Sigal, S. AU - Bourliere, M. PY - 2007 DA - 2007// TI - Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C JO - N Engl J Med VL - 357 UR - https://doi.org/10.1056/NEJMoa073255 DO - 10.1056/NEJMoa073255 ID - McHutchison2007 ER - TY - JOUR AU - Will, B. AU - Kawahara, M. AU - Luciano, J. P. AU - Bruns, I. AU - Parekh, S. AU - Erickson-Miller, C. L. PY - 2009 DA - 2009// TI - Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome JO - Blood VL - 114 UR - https://doi.org/10.1182/blood-2009-04-219493 DO - 10.1182/blood-2009-04-219493 ID - Will2009 ER - TY - JOUR AU - Lin, P. AU - Owens, R. AU - Tricot, G. AU - Wilson, C. S. PY - 2004 DA - 2004// TI - Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma JO - Am J Clin Pathol VL - 121 UR - https://doi.org/10.1309/74R4TB90BUWH27JX DO - 10.1309/74R4TB90BUWH27JX ID - Lin2004 ER - TY - JOUR AU - Graf, G. AU - Dehmel, U. AU - Drexler, H. G. PY - 1996 DA - 1996// TI - Expression of thrombopoietin and thrombopoietin receptor MPL in human leukemia-lymphoma and solid tumor cell lines JO - Leuk Res VL - 20 UR - https://doi.org/10.1016/S0145-2126(96)00057-4 DO - 10.1016/S0145-2126(96)00057-4 ID - Graf1996 ER - TY - JOUR AU - Erickson-Miller, C. L. AU - Kirchner, J. AU - Aivado, M. AU - May, R. AU - Payne, P. AU - Chadderton, A. PY - 2010 DA - 2010// TI - Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag JO - Leuk Res VL - 34 UR - https://doi.org/10.1016/j.leukres.2010.02.005 DO - 10.1016/j.leukres.2010.02.005 ID - Erickson-Miller2010 ER - TY - JOUR AU - Dimopoulos, M. AU - Spencer, A. AU - Attal, M. AU - Prince, H. M. AU - Harousseau, J. L. AU - Dmoszynska, A. PY - 2007 DA - 2007// TI - Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma JO - N Engl J Med VL - 357 UR - https://doi.org/10.1056/NEJMoa070594 DO - 10.1056/NEJMoa070594 ID - Dimopoulos2007 ER - TY - JOUR AU - Birkmann, J. AU - Oez, S. AU - Smetak, M. AU - Kaiser, G. AU - Kappauf, H. AU - Gallmeier, W. M. PY - 1997 DA - 1997// TI - Effects of recombinant human thrombopoietin alone and in combination with erythropoietin and early-acting cytokines on human mobilized purified CD34+ progenitor cells cultured in serum-depleted medium JO - Stem Cells VL - 15 UR - https://doi.org/10.1002/stem.150018 DO - 10.1002/stem.150018 ID - Birkmann1997 ER - TY - JOUR AU - Erhardt, J. A. AU - Erickson-Miller, C. L. AU - Aivado, M. AU - Abboud, M. AU - Pillarisetti, K. AU - Toomey, J. R. PY - 2009 DA - 2009// TI - Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function JO - Exp Hematol VL - 37 UR - https://doi.org/10.1016/j.exphem.2009.06.011 DO - 10.1016/j.exphem.2009.06.011 ID - Erhardt2009 ER - TY - JOUR AU - Rodeghiero, F. AU - Ruggeri, M. PY - 2015 DA - 2015// TI - Treatment of immune thrombocytopenia in adults: the role of thrombopoietin-receptor agonists JO - Semin Hematol VL - 52 UR - https://doi.org/10.1053/j.seminhematol.2014.10.006 DO - 10.1053/j.seminhematol.2014.10.006 ID - Rodeghiero2015 ER - TY - JOUR AU - Laubach, J. P. AU - Mahindra, A. AU - Mitsiades, C. S. AU - Schlossman, R. L. AU - Munshi, N. C. AU - Ghobrial, I. M. PY - 2009 DA - 2009// TI - The use of novel agents in the treatment of relapsed and refractory multiple myeloma JO - Leukemia VL - 23 UR - https://doi.org/10.1038/leu.2009.179 DO - 10.1038/leu.2009.179 ID - Laubach2009 ER - TY - JOUR AU - Shah, J. J. AU - Orlowski, R. Z. PY - 2009 DA - 2009// TI - Proteasome inhibitors in the treatment of multiple myeloma JO - Leukemia VL - 23 UR - https://doi.org/10.1038/leu.2009.173 DO - 10.1038/leu.2009.173 ID - Shah2009 ER - TY - JOUR AU - Drexler, H. G. AU - Quentmeier, H. PY - 1996 DA - 1996// TI - Thrombopoietin: expression of its receptor MPL and proliferative effects on leukemic cells JO - Leukemia VL - 10 ID - Drexler1996 ER - TY - JOUR AU - Hellstrom-Lindberg, E. AU - Malcovati, L. PY - 2008 DA - 2008// TI - Supportive care and use of hematopoietic growth factors in myelodysplastic syndromes JO - Semin Hematol VL - 45 UR - https://doi.org/10.1053/j.seminhematol.2007.10.004 DO - 10.1053/j.seminhematol.2007.10.004 ID - Hellstrom-Lindberg2008 ER - TY - JOUR AU - Jadersten, M. AU - Malcovati, L. AU - Dybedal, I. AU - Della Porta, M. G. AU - Invernizzi, R. AU - Montgomery, S. M. PY - 2008 DA - 2008// TI - Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic syndrome JO - J Clin Oncol VL - 26 UR - https://doi.org/10.1200/JCO.2007.15.4906 DO - 10.1200/JCO.2007.15.4906 ID - Jadersten2008 ER - TY - JOUR AU - Shehata, N. AU - Walker, I. AU - Meyer, R. AU - Haynes, A. E. AU - Imrie, K. PY - 2008 DA - 2008// TI - The use of erythropoiesis-stimulating agents in patients with non-myeloid hematological malignancies: a systematic review JO - Ann Hematol VL - 87 UR - https://doi.org/10.1007/s00277-008-0525-5 DO - 10.1007/s00277-008-0525-5 ID - Shehata2008 ER - TY - JOUR AU - Katodritou, E. AU - Verrou, E. AU - Hadjiaggelidou, C. AU - Gastari, V. AU - Laschos, K. AU - Kontovinis, L. PY - 2008 DA - 2008// TI - Erythropoiesis-stimulating agents are associated with reduced survival in patients with multiple myeloma JO - Am J Hematol VL - 83 UR - https://doi.org/10.1002/ajh.21239 DO - 10.1002/ajh.21239 ID - Katodritou2008 ER - TY - JOUR AU - Blair, A. AU - Baker, C. L. AU - Pamphilon, D. H. AU - Judson, P. A. PY - 2002 DA - 2002// TI - Ex vivo expansion of megakaryocyte progenitor cells from normal bone marrow and peripheral blood and from patients with haematological malignancies JO - Br J Haematol VL - 116 UR - https://doi.org/10.1046/j.0007-1048.2002.03354.x DO - 10.1046/j.0007-1048.2002.03354.x ID - Blair2002 ER - TY - JOUR AU - Somlo, G. AU - Sniecinski, I. AU - Veer, A. AU - Longmate, J. AU - Knutson, G. AU - Vuk-Pavlovic, S. PY - 1999 DA - 1999// TI - Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy JO - Blood VL - 93 ID - Somlo1999 ER - TY - JOUR AU - Li, J. AU - Yang, C. AU - Xia, Y. AU - Bertino, A. AU - Glaspy, J. AU - Roberts, M. PY - 2001 DA - 2001// TI - Thrombocytopenia caused by the development of antibodies to thrombopoietin JO - Blood VL - 98 UR - https://doi.org/10.1182/blood.V98.12.3241 DO - 10.1182/blood.V98.12.3241 ID - Li2001 ER - TY - JOUR AU - Hogge, D. AU - Fanning, S. AU - Bockhold, K. AU - Petzer, A. AU - Lambie, K. AU - Lansdorp, P. PY - 1997 DA - 1997// TI - Quantitation and characterization of human megakaryocyte colony-forming cells using a standardized serum-free agarose assay JO - Br J Haematol VL - 96 UR - https://doi.org/10.1046/j.1365-2141.1997.d01-2092.x DO - 10.1046/j.1365-2141.1997.d01-2092.x ID - Hogge1997 ER -