Figure 5From: The non-peptide thrombopoietin receptor agonist eltrombopag stimulates megakaryopoiesis in bone marrow cells from patients with relapsed multiple myelomaEltrombopag stimulates the expansion of hematopoietic progenitor cells from normal controls. CD34+ cells cultured in the presence or absence of 10 μM eltrombopag or 100 ng/ml rhTPO for 11 days were assessed for pluripotency by hematopoietic progenitor assays performed in semi-solid methylcellulose or MegaCult media. (A) CFU-E, (B) BFU-E, (C) CFU-GM, and (D) CFU-GEMM were enumerated at the end of 14 days and (E) CFU-Mk at the end of 12 days. Data are presented as mean ± S.E. relative to control from eight individual donors with experiments performed in triplicate. CTRL = control; ELT = Eltrombopag; TPO = thrombopoietin. * p < 0.02, ** p < 0.01.Back to article page