Figure 8

Oroxylin A inhibited the growth-transplanted human tumor. Nude mice inoculated with MCF-7 cells were treated with saline control, oroxylin A (100 mg/kg), and PTX (15 mg/kg). Nude mice inoculated with HCT116 cells were treated with saline control, oroxylin A (100 mg/kg), and 5-FU (20 mg/kg). (A) The tumor inhibitory rates were calculated. (B) Quantitative RT-PCR on RNA isolated from xenograft tumors. (C) The tumor tissue protein expressions of xenograft tumors were assayed by immunoblotting. (D) Proteins expression in breast tumor tissue were assessed by immunohistochemistry. All the Western blot bands were quantified. Bars, SD; *p < 0.05 or **p < 0.01 versus non-treated control.