Skip to main content

Table 3 Overall survival of patients with therapy-related myeloid neoplasm by univariate and multivariate analysis

From: TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

Variables Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Age (>60 years) 1.001 0.572–1.753 0.997 0.995 0.553–1.792 0.988
Gender (man) 0.708 0.438–1.143 0.157 0.541 0.315–0.927 0.025
ANC (<0.8 × 109/L) 1.313 0.821–2.099 0.256 0.820 0.482–1.392 0.462
BM blast (≥5%) 1.633 0.941–2.836 0.081 1.580 0.853–2.924 0.145
Hemoglobin (<100 g/L) 1.946 1.153–3.286 0.013 1.711 0.950–3.081 0.073
Platelet (<50 × 109/L) 2.181 1.291–3.683 0.004 2.023 1.153–3.549 0.014
Complex karyotype 2.878 1.694–4.888 <0.001 1.150 0.546–2.425 0.713
TP53 mutation 2.971 1.823–4.841 <0.001 2.958 1.476–5.929 0.002
  1. Abbreviations: HR, hazard ratio; CI, confidence interval; ANC, absolute neutrophil count; BM, bone marrow.
  2. p value < 0.05 is demonstrated in italics.