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Figure 6 | Journal of Hematology & Oncology

Figure 6

From: The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression

Figure 6

Effect of GAS5 and gefitinib on the activity of the EGFR/PI3K/AKT pathway and IGF-1R in A549 cells. (A) Significant suppression of EGFR and downstream signaling molecules are seen following co-treatment with GAS5 and gefitinib. Dose-dependent downregulation of IGF-1R protein was also seen. (B) Relative levels of P-EGFR, P-AKT, P-ERK and P-IGF-1R proteins expression in six groups. The data represent the mean ± SD from three independent experiments. *P < 0.05

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Journal of Hematology & Oncology

ISSN: 1756-8722

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